Most Recent Publications

2021Interleukin-22 mitigates acute respiratory distress syndrome (ARDS)
2021Interleukin 22 mitigates endothelial glycocalyx shedding after lipopolysaccharide injury
2020Interleukin-22 drives a metabolic adaptive reprogramming to maintain mitochondrial fitness and treat liver injury
2020Interleukin-22 inhibits respiratory syncytial virus
production by blocking virus-mediated subversion of cellular autophagy
2020IL-22 receptor signaling in paneth cells is critical for their maturation, microbiota colonization, Th17-related immune responses, and anti-salmonella immunity
2020Interleukin-22 ameliorates neutrophil-driven nonalcoholic steatohepatitis through multiple targets
2020Interleukin-22 ameliorates acute-on-chronic liver failure by reprogramming impaired regeneration pathways in mice
2019An open-label, dose-escalation study to assess the safety and efficacy of IL-22 agonist F-652 in patients with alcohol-associated hepatitis
2019Targeting the IL-22/IL-22BP axis enhances tight junctions and reduces inflammation during influenza infection
2018Safety, pharmacokinetics, and biomarkers of F-652, a recombinant human interleukin-22 dimer, in healthy subjects
2018Liver-heart crosstalk controls IL-22 activity in cardiac protection after myocardial infarction
2018Enhanced regeneration and hepatoprotective effects of interleukin 22 fusion protein on a predamaged liver undergoing partial hepatectomy
2016Critical role of IL-22/IL22-RA1 signaling in pneumococcal pneumonia
2015Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration
2015Biologically active, high levels of interleukin-22 inhibit hepatic gluconeogenesis but do not affect obesity and its metabolic consequences